Migraines hit you unexpectedly, and when they do, it feels like your head is throwing a party with a thousand trumpets and drums! What if we told you the reason behind those headaches hides in an unexpected place—your gut? Surprised? Come, let’s uncover the migraine gut imbalance link!
We’re so desperate to calm the throbbing headache with a balm or mild painkiller. But are their effects long-lasting? Just when you think you've found relief, another wave of pain crashes down, leaving you feeling helpless and frustrated. What does your gut have to do with these persistent migraines?
There’s a growing buzz about the migraine gut imbalance connection. Your gut, believe it or not, is like a second brain, sending signals to the rest of your body. When things go awry in your gut, it can trigger a chain reaction, even leading to migraines. We’ll look into this connection between your head and tummy in detail through this blog. So, get ready to discover a few fascinating studies!
What is a migraine?
Migraine is a neurological disorder that affects millions worldwide. When someone says they have a migraine, we usually disregard it as merely a headache. In reality, it can significantly impact a person’s quality of life and wear them out. Here are a few common signs of a migraine:
- Severe headache
- Pulsing sensation
- Extreme sensitivity to light and sound
- Nausea
- Vomiting
- Neck stiffness
Do these symptoms occur at the same time? Not necessarily. Before learning the migraine gut imbalance link, let’s understand the 4 distinct phases of migraine attacks:
- Premonitory (Prodrome) phase: This phase occurs hours or even days before the actual headache when your body sends out warning signals. You might experience symptoms like mood swings, irritability, difficulty concentrating, food cravings, or increased urination. These premonitory symptoms are believed to be linked to changes in brain chemistry, particularly involving the hypothalamus, a part of the brain that regulates many bodily functions.
- Aura phase: Not everyone experiences an aura, but when it happens, it's usually a visual disturbance. You might see flashing lights, zigzag patterns, or blind spots. This phase is often associated with cortical spreading depression, an electrical wave that travels across the brain's surface.
- Headache phase: It is the most recognisable phase of a migraine. The pain can be throbbing, pulsating, or severe, often accompanied by nausea, vomiting, sensitivity to light and sound (photophobia and phonophobia), and neck stiffness.
- Postdrome phase: After the headache subsides, you might feel drained, exhausted, and confused. That’s the postdrome phase. While the intense pain is gone, you might experience lingering effects like brain fog or difficulty concentrating.
Understanding these phases can help you identify potential migraine triggers and develop strategies to manage your symptoms. Migraine is a complex condition, and the migraine gut imbalance theory suggests that there’s a connection between your gut and the brain.
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The link between gut imbalance and migraine

The importance of gut health has long been established, and yet many are still confused about how it affects your overall health. Your gut is home to trillions of bacteria, both good and harmful ones. A balanced gut plays a vital role in digestion, nutrient absorption, and immune function. Here, we’ll look at the migraine gut imbalance relationship through the concept of the gut-brain axis.
The gut and brain are constantly communicating through the gut-brain axis. The brain sends signals to the gut, affecting digestion and gut bacteria, while your gut, in turn, influences brain function and mood. When the delicate balance of gut bacteria is disrupted, it can trigger several events that contribute to migraine development:
- Neural signals: The vagus nerve, a primary communication channel between the gut and brain, carries information about the gut's state to the brain and vice versa.
- Hormonal signals: The gut produces hormones like serotonin and dopamine, which can influence our moods. An imbalance in gut bacteria can disrupt serotonin production, leading to migraine-related symptoms like mood swings, sleep disturbances, and digestive issues.
- Immune signals: Your gut is home to a vast network of immune cells. When your gut health is compromised, it can trigger an inflammatory response that affects the brain and contributes to migraine development.
- Metabolic signals: The bacteria in your gut produce short-chain fatty acids, which have anti-inflammatory properties and can influence brain function. An imbalance in gut bacteria can disrupt this process, potentially leading to migraine.
- Gut disorders: People with migraines are more likely to experience gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease. These conditions are often associated with gut microbiota imbalances, further strengthening the link between migraine and gut health.
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Who would have thought those tiny gut bacteria hold a mysterious key to migraine? Now, let’s explore how to manage migraines with diet and gut microbes.
Diet and gut microbiota in migraine management
Diet is crucial for maintaining your health, but how does it impact migraine frequency and severity? Did you know certain foods can trigger migraine attacks while some may also help prevent them? By understanding the connection between diet, gut microbiota, and migraines, you can take steps to manage your condition effectively.
Here are some of the common food triggers experienced by people with migraine. They can vary from person to person but include the following:
- Processed foods: Contain additives like monosodium glutamate (MSG), artificial sweeteners, and preservatives.
- Caffeine: While it can provide temporary relief for some, excessive caffeine consumption can lead to withdrawal headaches.
- Alcohol: Certain types of alcohol, especially red wine, can trigger migraines in some individuals.
- Aged cheeses: These contain tyramine, a substance that can cause migraines.
- Chocolate: While enjoyed by many, chocolate contains compounds that can lead to severe headaches in susceptible individuals.
So, you’ve identified the culprits in your diet. Now, it’s time to follow a diet that has shown promise in migraine prevention and management:
- Elimination diets: By systematically removing potential triggers from your diet, you can identify foods that contribute to your migraines. Once you've identified your triggers, you can reintroduce them gradually to confirm their impact.
- Targeted diets: Certain diets focus on specific nutrients or macronutrients. For example, the ketogenic diet, low-glycemic index diet, and diets emphasising omega-3 fatty acids have been explored for their potential benefits in migraine prevention.
- Overall healthy diets: Following dietary patterns like the DASH (Dietary Approaches to Stop Hypertension) or Mediterranean diet can provide a solid foundation for overall health and may also help manage migraines. These diets are rich in fruits, vegetables, whole grains, and healthy fats, which support gut health and reduce inflammation.
Finding the right dietary approach is often a matter of trial and error. Keeping a food diary can help you identify your triggers and track the effectiveness of different dietary strategies. While diet can be a powerful tool in migraine management, it's essential to consult with a healthcare professional or registered dietitian for personalised guidance.
Prebiotics and probiotics in migraine management
The reason for migraine lies in the gut, so shouldn’t the solution also come from it? If migraines come from an imbalanced gut, the best way is to restore good bacteria in your gut. And there’s nothing more effective than prebiotics and probiotics. While the research in this area is still ongoing, we can say that bringing beneficial bacteria through prebiotics and probiotics can potentially alleviate migraine symptoms.
Both work in different ways to influence the gut microbiome:
- Prebiotics: These are specialised plant fibers that act as food for beneficial gut bacteria. By promoting the growth of healthy bacteria, prebiotics can help restore balance to the microbiome.
- Probiotics: These are live microorganisms that can confer health benefits when consumed in adequate amounts. They can directly replenish the gut with beneficial bacteria, helping to counteract the effects of an imbalanced microbiome.
A variety of probiotic strains are being studied for their potential benefits in migraine management. Some examples include:
- Lactobacillus: This genus of bacteria is commonly found in probiotic supplements and fermented foods. Certain Lactobacillus strains have shown promise in reducing migraine frequency and severity.
- Bifidobacterium: Another beneficial genus of bacteria, Bifidobacterium, has been investigated for its potential to improve gut health and reduce inflammation.
- Other strains: Research is also exploring the effects of other probiotic strains, such as Bacillus subtilis and Saccharomyces boulardii, on migraine.
While more research is needed, some studies have suggested that probiotics may offer the following benefits for people with migraines:
- Reduced migraine frequency: Regular consumption of probiotics may help decrease the number of migraine attacks.
- Decreased migraine severity: Probiotics may help alleviate the intensity of migraine symptoms.
- Improved gut health: By restoring balance to the gut microbiome, probiotics can support overall gut health and reduce inflammation.
Migraines can be a real headache, but understanding the migraine gut imbalance connection is a giant leap towards finding relief. By making conscious choices about your diet, lifestyle, and gut health, you’re taking control of your well-being.
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References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536453/
https://www.sciencedirect.com/science/article/pii/S2452073X22000071
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609600/
https://www.news-medical.net/health/-Is-There-a-Link-Between-Migraine-and-The-Gut-Microbiome.aspx
https://www.migraineagain.com/gut-brain-connection-migraine/
https://www.nature.com/articles/s41598-023-27586-4
https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-1078-9